GNF351

GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes[1].

Research Areas >> Others

Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor

IC50: 62 nM (aryl hydrocarbon receptor)[1]

GNF351 (500 nM, 48 hours) significantly reduces the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes[1]. Cell Proliferation Assay[1] Cell Line: Human primary keratinocytes Concentration: 500 nM Incubation Time: 48 hours Result: Showed a significant reduction in the percentage of Ki67-positive cells and cell number after treating proliferating monolayer cultures of human keratinocytes for 48 hours.

[1]. van den Bogaard EH，et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.