FLLL32

Names

[ Name ]:
FLLL32

[Synonym ]:
MFCD22200575

Biological Activity

[Description]:

FLLL32 is a STAT3 inhibitor derived from the natural product curcumin. FLLL32 retains the cellular response to cytokines with anti-tumor activity[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> STAT

[Target]

STAT3[1]

[In Vitro]

FLLL32 specifically reduces STAT3 phosphorylation at Tyr705 (pSTAT3) and induces apoptosis at micromolar amounts in human melanoma cell lines and primary melanoma cultures[1].

[References]

[1]. Bill MA, et al. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3inhibition and retains the cellular response to cytokines with anti-tumor activity. Mol Cancer. 2010 Jun 25;9:165.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₂O₆

[ Molecular Weight ]:
464.55

[ Exact Mass ]:
464.22000

[ PSA ]:
71.06000

[ LogP ]:
5.53630

[ Storage condition ]:
-20℃