1226895-15-3

1226895-15-3 structure

Name: FLLL32
Chemical Name: flll32
CAS Number: 1226895-15-3
Molecular Formula: C₂₈H₃₂O₆
Molecular Weight: 464.55
Catalog: Signaling Pathways JAK/STAT Signaling STAT
Create Date: 2018-06-28 01:51:11
Modify Date: 2024-01-06 21:49:38
FLLL32 is a STAT3 inhibitor derived from the natural product curcumin. FLLL32 retains the cellular response to cytokines with anti-tumor activity[1].

Name	flll32
Synonyms	MFCD22200575

Description	FLLL32 is a STAT3 inhibitor derived from the natural product curcumin. FLLL32 retains the cellular response to cytokines with anti-tumor activity[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT
Target	STAT3[1]
In Vitro	FLLL32 specifically reduces STAT3 phosphorylation at Tyr705 (pSTAT3) and induces apoptosis at micromolar amounts in human melanoma cell lines and primary melanoma cultures[1].
References	[1]. Bill MA, et al. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3inhibition and retains the cellular response to cytokines with anti-tumor activity. Mol Cancer. 2010 Jun 25;9:165.