VU591

Names

[ Name ]:
VU591

[Synonym ]:
2,2 inverted exclamation marka-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole)
ML112
2,2 inverted exclamation marka-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole)
5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole
VU591

Biological Activity

[Description]:

VU591 is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 0.24 μM (ROMK)[1].

[References]

[1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₂N₆O₅

[ Molecular Weight ]:
368.30

[ Exact Mass ]:
368.08700

[ PSA ]:
158.23000

[ LogP ]:
4.01880

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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