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prepro-thyrotropin releasing hormone (160-169)

Names

[ CAS No. ]:
122018-91-1

[ Name ]:
prepro-thyrotropin releasing hormone (160-169)

[Synonym ]:
L-Threonine, L-seryl-L-phenylalanyl-L-prolyl-L-tryptophyl-L-methionyl-L-α-glutamyl-L-seryl-L-α-aspartyl-L-valyl-
L-Seryl-L-phenylalanyl-L-prolyl-L-tryptophyl-L-methionyl-L-α-glutamyl-L-seryl-L-α-aspartyl-L-valyl-L-threonine

Biological Activity

[Description]:

Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> Others >> Thyroid Hormone Receptor
Research Areas >> Neurological Disease

[In Vitro]

在大鼠垂体前叶细胞的原代培养物中，Prepro-TRH-(160-169) (Ps4) 能够在 15 秒内迅速增加细胞内 Ca2+ 浓度（[Ca2+] i) [2]。

[In Vivo]

在氨基甲酸乙酯麻醉的大鼠中，Prepro-TRH-(160-169)（Ps4；100 ng、150 ng 和 200 ng；注入背运动核 (DMN)）通过肽和位点特异性的作用增强 DMN 诱发的胃酸分泌中的 TRH： 是肽和位点特异性的[1]。

[References]

[1]. H Yang, et al. Prepro-TRH-(160-169) potentiates gastric acid secretion stimulated by TRH microinjected into the dorsal motor nucleus of the vagus. Neurosci Lett. 1994 Jun 6;174(1):43-6.  

[2]. J P Roussel, et al. Somatostatin blocks the potentiation of TRH-induced TSH secretion from perifused pituitary fragments and the change in intracellular calcium concentrations from dispersed pituitary cells elicited by prepro-TRH (PS4) or by tri-iodothyronine. J Mol Endocrinol. 1997 Aug;19(1):87-97.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1696.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C54H75N11O18S

[ Molecular Weight ]:
1198.301

[ Flash Point ]:
979.6±34.3 °C

[ Exact Mass ]:
1197.501221

[ LogP ]:
0.58

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.619

Related Compounds