4-CPA
Names
[ CAS No. ]:
122-88-3
[ Name ]:
4-CPA
[Synonym ]:
parachlorophenoxyacetic acid
Sure-Set
tomatofix
QV1OR DG
4-CPA
EINECS 204-581-3
Acetic acid, (4-chlorophenoxy)-
Acetic acid, 2-(4-chlorophenoxy)-
marks4-cpa
MFCD00004305
4-Chlorophenoxyacetic acid
4-ChFU
2-(4-Chlorophenoxy)acetic acid
4-CP
(4-Chlorophenoxy)acetic acid
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
315.2±17.0 °C at 760 mmHg
[ Melting Point ]:
157-159 °C
[ Molecular Formula ]:
C8H7ClO3
[ Molecular Weight ]:
186.592
[ Flash Point ]:
144.4±20.9 °C
[ Exact Mass ]:
186.008377
[ PSA ]:
46.53000
[ LogP ]:
2.03
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.558
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AG0175000
- CHEMICAL NAME :
- Acetic acid, (p-chlorophenoxy)-
- CAS REGISTRY NUMBER :
- 122-88-3
- BEILSTEIN REFERENCE NO. :
- 1211804
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C8-H7-Cl-O3
- MOLECULAR WEIGHT :
- 186.60
- WISWESSER LINE NOTATION :
- QV1OR DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 850 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 680 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Human Cells - not otherwise specified
- DOSE/DURATION :
- 10 mmol/L
- REFERENCE :
- ZYDXDM Zhejiang Yike Daxue Xuebao. Journal of Zhejiang Medical University. (Zhejiang Yike Daxue, Yan'an Lu, Hanzhou, Zhejiang, Peop. Rep. China) V.1- 1972(?)- Volume(issue)/page/year: 13(2),74,1984 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S22
[ RIDADR ]:
2811
[ WGK Germany ]:
1
[ RTECS ]:
AG0175000
[ HS Code ]:
2916399014
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2916399014
[ Summary ]:
2916399014 。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%
Articles
J. Med. Chem. 52 , 6931-5, (2009)
We show that phenoxyauxin herbicides and lipid-lowering fibrates inhibit human but not rodent T1R3. T1R3 as a coreceptor in taste cells responds to sweet compounds and amino acids; in endocrine cells ...
Amphiphilic blockers punch through a mutant CLC-0 pore.J. Gen. Physiol. 133(1) , 59-68, (2009)
Intracellularly applied amphiphilic molecules, such as p-chlorophenoxy acetate (CPA) and octanoate, block various pore-open mutants of CLC-0. The voltage-dependent block of a particular pore-open muta...
Molecular modeling of p-chlorophenoxyacetic acid binding to the CLC-0 channel.Biochemistry 42(18) , 5176-85, (2003)
Molecular simulation techniques were applied to predict the interaction of the CLC-0 Cl(-) channel and the channel-blocking molecule p-chlorophenoxyacetic acid (CPA). A three-dimensional model of the ...