Lansoprazole Sulfide D4

Names

[ Name ]:
Lansoprazole Sulfide D4

[Synonym ]:
K 1252-d4
H 225/18-d4
2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]thio]-1H-benzimidazole-d4
AG 1777-d4
Lansoprazole Sulfide-d4
[2H4]-Lansoprazole sulfide

Biological Activity

[Description]:

Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an active metabolite of the proton pump inhibitor Lansoprazole. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 µM intracellularly and 0.46 µM in broth[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Proton pump[1] IC50: 0.59 µM (Mycobacterium tuberculosis intracellularly), 0.46 µM (Mycobacterium tuberculosis in broth)[1]

[References]

[1]. Mdanda S, et al. Lansoprazole-sulfide, pharmacokinetics of this promising anti-tuberculous agent. Biomed Chromatogr. 2017 Dec;31(12).

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₀D₄F₃N₃OS

[ Molecular Weight ]:
357.38700

[ Exact Mass ]:
357.10600

[ PSA ]:
76.10000

[ LogP ]:
4.49970

Related Compounds

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