Ketorolac D5

Names

[ Name ]:
Ketorolac D5

[Synonym ]:
1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-(phenyl-d5-carbonyl)-
5-[(2H5)Phenylcarbonyl]-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

Biological Activity

[Description]:

Ketorolac D5 is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-1:20 nM (IC50)

COX-2:120 nM (IC50)

[References]

[1]. Waterbury LD, et al. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
493.2±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₈D₅NO₃

[ Molecular Weight ]:
260.299

[ Flash Point ]:
252.1±27.3 °C

[ Exact Mass ]:
260.120941

[ LogP ]:
2.08

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.659

Related Compounds

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