CTP354

Names

[ Name ]:
CTP354

[Synonym ]:
1,2,4-Triazolo[4,3-b]pyridazine, 3-(2,5-difluorophenyl)-7-[1,1-di(methyl-d)ethyl-2,2,2-d]-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-
3-(2,5-Difluorophenyl)-7-[2-(H)methyl(H)-2-propanyl]-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy][1,2,4]triazolo[4,3-b]pyridazine

Biological Activity

[Description]:

L-838417 D9 is the deuterium labeled L-838417. L-838417 is a subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Hofmann M, et al. Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function [published correction appears in Behav Pharmacol. 2013 Apr;24(2):153]. Behav Pharmacol. 2012;23(8):790-801.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₁₉H₁₉F₂N₇O

[ Molecular Weight ]:
408.453

[ Exact Mass ]:
408.218414

[ LogP ]:
2.80

[ Index of Refraction ]:
1.655

Related Compounds

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