[18F]AZD4694 Precursor

Names

[ Name ]:
[18F]AZD4694 Precursor

[Synonym ]:
2-Methyl-2-propanyl {5-[5-(ethoxymethoxy)-1-benzofuran-2-yl]-6-nitro-2-pyridinyl}methylcarbamate
Carbamic acid, N-[5-[5-(ethoxymethoxy)-2-benzofuranyl]-6-nitro-2-pyridinyl]-N-methyl-, 1,1-dimethylethyl ester

Biological Activity

[Description]:

[18F]AZD4694 Precursor is the precursor of [18F] AZD4694 for the synthesis of [18F] AZD4694, an amyloid-β imaging ligand with high affinity for amyloid-β plaques[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

18F-AZD4694 is an amyloid-β imaging ligand with high affinity for amyloid-β plaques. 18F-AZD4694 is a high affinity (Kd= 2.3 nM) radioligand for imaging amyloid-β plaques that displays lower white matter binding compared to other fluorinated amyloid-PET tracers, enabling easier visual reads[1].

[References]

[1]. Therriault J, et al. Determining Amyloid-β Positivity Using 18F-AZD4694 PET Imaging. J Nucl Med. 2021;62(2):247-252.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
593.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₅N₃O₇

[ Molecular Weight ]:
443.45

[ Flash Point ]:
312.7±30.1 °C

[ Exact Mass ]:
443.169250

[ LogP ]:
3.65

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.594

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.