L-670,596

Names

[ Name ]:
L-670,596

[Synonym ]:
R 568 hydrochloride
HMS3268M18
L-670,596

Biological Activity

[Description]:

L-670596 is an orally active and selective thrombsxane A2 receptor/prostaglandin receptor antagonist. L-670596 inhibits arachidonic acid (HY-109590) and U-44069 induced bronchoconstriction in the guinea pig. L-670596 also inhibits the aggregation of human platelet rich plasma induced by U-44069[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

[In Vitro]

L-670596 抑制 U-44069 诱导的人类富血小板血浆的聚集[1]。

[In Vivo]

L-670596 (0.03 mg/kg ; i.v.; single) 抑制豚鼠中花生四烯酸和 U-44069 诱导的支气管收缩[1]。 L-670596 (2 mg/kg; i.v.; single) 抑制猪的血小板聚集成胶原蛋白[2]。 Animal Model: Guinea pig (arachidonic acid and U-44069 induced bronchoconstriction model)[1]. Dosage: 0.03mg/kg Administration: Intravenous injection; single. Result: Inhibited arachidonic acid and U-44069 induced bronchoconstriction.

[References]

[1]. Ford-Hutchinson AW, et al. The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist. Can J Physiol Pharmacol. 1989 Sep;67(9):989-93.

[2]. Nuttall GA, et al. Protamine-heparin-induced pulmonary hypertension in pigs: effects of treatment with a thromboxane receptor antagonist on hemodynamics and coagulation. Anesthesiology. 1991 Jan;74(1):138-45.

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Boiling Point ]:
693.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₁F₂NO₄S

[ Molecular Weight ]:
433.47

[ Flash Point ]:
373.2ºC

[ Exact Mass ]:
433.11600

[ PSA ]:
84.75000

[ LogP ]:
5.34670

[ Vapour Pressure ]:
3.46E-20mmHg at 25°C

[ Index of Refraction ]:
1.636

Related Compounds

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