Cyclotrimethylenetrinitramine
Names
[ CAS No. ]:
121-82-4
[ Name ]:
Cyclotrimethylenetrinitramine
[Synonym ]:
T4
Geksogen
cyclo-trimethylene-trinitramine
Cyclonite
RDX
Hexogeen
1,3,5-trinitrohexahydro-s-triazine
1,3,5-TRINITROHEXAHYDRO-1,3,5-TRIAZINE
sym-Trimethylenetrinitramine
cyclotrimethylenetrinitroamine
hexogen
Heksogen
Hexahydro-1,3,5-trinitro-1,3,5-triazine
1,3,5-Triazine, hexahydro-1,3,5-trinitro-
EINECS 204-500-1
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)
1,3,5-trinitro-1,3,5-triazacyclohexane
cx84a
1,3,5-Trinitro-1,3,5-triazinane
khp281
Cyklonit
Spherical 1,3,5-trinitro-1,3,5-triazacyclohexane
pe4
Chemical & Physical Properties
[ Density]:
1.9±0.1 g/cm3
[ Boiling Point ]:
747.0±50.0 °C at 760 mmHg
[ Melting Point ]:
205ºC
[ Molecular Formula ]:
C3H6N6O6
[ Molecular Weight ]:
222.116
[ Flash Point ]:
405.6±30.1 °C
[ Exact Mass ]:
222.034882
[ PSA ]:
147.18000
[ LogP ]:
-2.19
[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C
[ Index of Refraction ]:
1.669
[ Stability ]:
Stability Unstable. Explosive.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XY9450000
- CHEMICAL NAME :
- s-Triazine, hexahydro-1,3,5-trinitro-
- CAS REGISTRY NUMBER :
- 121-82-4
- BEILSTEIN REFERENCE NO. :
- 0288466
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 40
- MOLECULAR FORMULA :
- C3-H6-N6-O6
- MOLECULAR WEIGHT :
- 222.15
- WISWESSER LINE NOTATION :
- T6N CN ENTJ ANW CNW ENW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 85 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 24,305,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 39,531,1977
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EATR** U.S. Army, Edgewood Arsenal Technical Report. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: EB-TR-73040
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EATR** U.S. Army, Edgewood Arsenal Technical Report. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: EB-TR-73040
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 59 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A092-531
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 19 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- EATR** U.S. Army, Edgewood Arsenal Technical Report. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: EB-TR-73040
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 7,43,1944
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 7,43,1944
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EATR** U.S. Army, Edgewood Arsenal Technical Report. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: EB-TR-73040 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3600 mg/kg/90D-C
- TOXIC EFFECTS :
- Cardiac - other changes Blood - pigmented or nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A092-531
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 28800 mg/kg/90D-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A092-531
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1800 mg/kg/6W-I
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Gastrointestinal - other changes Related to Chronic Data - death
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 31,21,1949 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 10 gm/kg
- SEX/DURATION :
- male 13 week(s) pre-mating female 13 week(s) pre-mating - 22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth)
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A092-531
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3 gm/kg
- SEX/DURATION :
- male 13 week(s) pre-mating female 13 week(s) pre-mating - 22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A092-531
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 20 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD-A166-249 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 1.5 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,221,1971 OSHA PEL (Construc):8H TWA 1.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 1.5 mg/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1.5 mg/m3;STEL 3 mg/m3;Skin JAN 1993 OEL-BELGIUM:TWA 1.5 mg/m3;STEL 3 mg/m3;Skin JAN 1993 OEL-DENMARK:TWA 1.5 mg/m3;Skin JAN 1993 OEL-FINLAND:TWA 1.5 mg/m3;STEL 4.5 mg/m3;Skin JAN 1993 OEL-FRANCE:TWA 1.5 mg/m3;Skin JAN 1993 OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 1.5 mg/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.4 mg/m3;Skin JAN 1993 OEL-POLAND:TWA 1 mg/m3 JAN 1993 OEL-RUSSIA:STEL 1 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 1.5 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 1.5 mg/m3;STEL 3 mg/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CYCLONITE-air:10H TWA 1.5 mg/m3;STEL 3 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0317 No. of Facilities: 20 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 242 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0317 No. of Facilities: 36 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 488 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H302 + H332-H319-H373
[ Precautionary Statements ]:
P210-P305 + P351 + P338
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R11
[ Safety Phrases ]:
16-27-45
[ RIDADR ]:
0072
[ Hazard Class ]:
1.1
[ HS Code ]:
2933990070
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990070
[ Summary ]:
2933990070 1,3,5-trinitro-1,3,5-triazinane。supervision conditions:3(export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%
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The large-scale production and processing of munitions has led to vast environmental pollution by the compounds TNT(2,4,6-trinitrotoluene), RDX(hexahydro-1,3,5-trinitro-1,3,5-triazine) and HMX(octahyd...
Direct liquid deposition calibration method for trace cyclotrimethylenetrinitramine using thermal desorption instrumentation.J. Chromatogr. A. 1282 , 178-82, (2013)
A simple method for establishing calibration curves with sorbent-filled thermal desorption tubes has been demonstrated for nitroaromatic and nitramine vapor samples using a thermal desorption system w...