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Isoliquiritin apioside

Names

[ CAS No. ]:
120926-46-7

[ Name ]:
Isoliquiritin apioside

[Synonym ]:
2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-[4-[[2-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-
4-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside
Neolicuroside

Biological Activity

[Description]:

Isoliquiritin apioside, a component isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

MMP9

NF-κB

p38 MAPK


[In Vitro]

Isoliquiritin apioside efficiently suppresses the PMA-induced gelatinolytic MMP-9 activity in HT1080 cells. Isoliquiritin apiosidealso decreases the PMA-induced increase in MMP-9 production in HT1080 cells.Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and endothelial cells (ECs), with no cytotoxicity[1].

[References]

[1]. Kim A1, et al. Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol. 2018 Dec 10;9:1455.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
901.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H30O13

[ Molecular Weight ]:
550.509

[ Flash Point ]:
301.9±27.8 °C

[ Exact Mass ]:
550.168640

[ PSA ]:
215.83000

[ LogP ]:
1.96

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.709

Related Compounds

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