(RS)-PPG

Names

[ CAS No. ]:
120667-15-4

[ Name ]:
(RS)-PPG

[Synonym ]:
4-phosphonophenylglycine

Biological Activity

[Description]:

(RS)-PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

hmGluR4a:5.2 μM (EC50)

hmGluR6:4.7 μM (EC50)

hmGluR7b:185 μM (EC50)

hmGluR8a:0.2 μM (EC50)

[In Vitro]

Activation of group III mGluRs by treatment of neurons with (R,S)-PPG (100 μM) can significantly suppress the elevation of intracellular calcium and protect neurons from apoptosis induced by Aβ[31-35] (25 μM)[2].

[References]

[1]. Gasparini F, et al. (R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J Pharmacol Exp Ther. 1999 Jun;289(3):1678-87.

[2]. Zhao L, et al. Activation of group III metabotropic glutamate receptor reduces intracellular calcium in beta-amyloid peptide [31-35]-treated cortical neurons. Neurotox Res. 2009 Aug;16(2):174-83.

Chemical & Physical Properties

[ Density]:
1.58 g/cm3

[ Boiling Point ]:
583.5ºC at 760 mmHg

[ Molecular Formula ]:
C₈H₁₀NO₅P

[ Molecular Weight ]:
231.14200

[ Exact Mass ]:
231.03000

[ PSA ]:
130.66000

[ LogP ]:
0.27430

[ Vapour Pressure ]:
1.85E-14mmHg at 25°C

[ Index of Refraction ]:
1.617

[ Storage condition ]:
Store at RT

[ Water Solubility ]:
DMSO: soluble2mg/mL

Related Compounds

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