BI-9627

Names

[ CAS No. ]:
1204329-34-9

[ Name ]:
BI-9627

Biological Activity

[Description]:

BI-9627 is a sodium−hydrogen exchanger isoform 1 (NHE1) inhibitor with an EC50 of 31 nM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Cardiovascular Disease

[Target]

EC50: 31 nM (Sodium−hydrogen exchanger isoform 1)[1]

[References]

[1]. Huber JD, et al. Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitableprofile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. J Med Chem. 2012 Aug 23;55(16):7114-40.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₉F₃N₄O₂

[ Molecular Weight ]:
356.34

Related Compounds

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