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(3R,4S,5S)-3-Methoxy-5-methyl-4-(methylamino)heptanoic Acid 1,1-Dimethylethyl Ester Hydrochloride

Names

[ CAS No. ]:
120205-48-3

[ Name ]:
(3R,4S,5S)-3-Methoxy-5-methyl-4-(methylamino)heptanoic Acid 1,1-Dimethylethyl Ester Hydrochloride

[Synonym ]:
tert-butyl trans(+-)-4-amino-3-hydroxypiperidine-1-carboxylate
Heptanoic acid, 3-methoxy-5-methyl-4-(methylamino)-, 1,1-dimethylethyl ester, (3R,4S,5S)-, hydrochloride (1:1)
(3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol
(3R,4R)-N-tert-butoxycarbonyl-3-hydroxy-4-hydroxymethylpyrrolidine
2-Methyl-2-propanyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoate hydrochloride (1:1)
tert-Butyl (3R,4S,5S)-3-methoxy-4-(N-methylamino)-5-methylheptanoate hydrochloride
(3R,4S,5S)-3-Methoxy-5-methyl-4-(methylamino)heptanoic Acid 1,1-Dimethylethyl Ester Hydrochloride
N-tert-butoxycarbonyl-(3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine
tert-butyl (3R*,4R*)-4-amino-3-hydroxy-piperidine-1-carboxylate
tert-butyl (3R,4S)-3-amino-4-hydroxy-azepan-1-carboxylate
(3R,4R)-1-tert-butoxycarbonyl-3-hydroxy-4-(hydroxymethyl)pyrrolidine
Dil tert-butyl ester hydrochloride
tert-butyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoate hydrochloride
(3R,4R)-tert-butyl 3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate
H-Dil-OtBu.HCl
(3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidin-1-N-carboxylic acid tert-butyl ester
(3R,4S,5S)-Dil-OBu-t*HCl
(3R,4S)-3-Amino-4-hydroxy-azepane-1-carboxylic acid tert-butyl ester
tert-butyl (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate
(3R,4S,5S)-3-methoxy-5-methyl-4-methylamino-heptanoic acid tert-butyl ester hydrochloride
(3R,4S,5S)-tert-butyl 3-methoxy-5-methyl-4-(methylamino)heptanoatehydrochloride
Diltiazem hydrochloride
(3R,4S,5S)-tert-butyl 3-Methoxy-5-Methyl-4-(MethylaMino)heptanoate hydroc hloride

Biological Activity

[Description]:

Monomethyl auristatin E intermediate-1 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.  

Chemical & Physical Properties

[ Molecular Formula ]:
C14H30ClNO3

[ Molecular Weight ]:
295.846

[ Exact Mass ]:
295.191437

[ PSA ]:
47.56000

[ LogP ]:
3.56020


Related Compounds

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