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120205-48-3

120205-48-3 structure
120205-48-3 structure
  • Name: (3R,4S,5S)-3-Methoxy-5-methyl-4-(methylamino)heptanoic Acid 1,1-Dimethylethyl Ester Hydrochloride
  • Chemical Name: 2-Methyl-2-propanyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino) heptanoate hydrochloride (1:1)
  • CAS Number: 120205-48-3
  • Molecular Formula: C14H30ClNO3
  • Molecular Weight: 295.846
  • Catalog: Research Areas Cancer
  • Create Date: 2018-10-07 20:08:24
  • Modify Date: 2025-09-01 18:18:03
  • Monomethyl auristatin E intermediate-1 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
Name 2-Methyl-2-propanyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino) heptanoate hydrochloride (1:1)
Synonyms tert-butyl trans(+-)-4-amino-3-hydroxypiperidine-1-carboxylate
Heptanoic acid, 3-methoxy-5-methyl-4-(methylamino)-, 1,1-dimethylethyl ester, (3R,4S,5S)-, hydrochloride (1:1)
(3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol
(3R,4R)-N-tert-butoxycarbonyl-3-hydroxy-4-hydroxymethylpyrrolidine
2-Methyl-2-propanyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoate hydrochloride (1:1)
tert-Butyl (3R,4S,5S)-3-methoxy-4-(N-methylamino)-5-methylheptanoate hydrochloride
(3R,4S,5S)-3-Methoxy-5-methyl-4-(methylamino)heptanoic Acid 1,1-Dimethylethyl Ester Hydrochloride
N-tert-butoxycarbonyl-(3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine
tert-butyl (3R*,4R*)-4-amino-3-hydroxy-piperidine-1-carboxylate
tert-butyl (3R,4S)-3-amino-4-hydroxy-azepan-1-carboxylate
(3R,4R)-1-tert-butoxycarbonyl-3-hydroxy-4-(hydroxymethyl)pyrrolidine
Dil tert-butyl ester hydrochloride
tert-butyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoate hydrochloride
(3R,4R)-tert-butyl 3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate
H-Dil-OtBu.HCl
(3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidin-1-N-carboxylic acid tert-butyl ester
(3R,4S,5S)-Dil-OBu-t*HCl
(3R,4S)-3-Amino-4-hydroxy-azepane-1-carboxylic acid tert-butyl ester
tert-butyl (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate
(3R,4S,5S)-3-methoxy-5-methyl-4-methylamino-heptanoic acid tert-butyl ester hydrochloride
(3R,4S,5S)-tert-butyl 3-methoxy-5-methyl-4-(methylamino)heptanoatehydrochloride
Diltiazem hydrochloride
(3R,4S,5S)-tert-butyl 3-Methoxy-5-Methyl-4-(MethylaMino)heptanoate hydroc hloride
Description Monomethyl auristatin E intermediate-1 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
Related Catalog
References

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.  

Molecular Formula C14H30ClNO3
Molecular Weight 295.846
Exact Mass 295.191437
PSA 47.56000
LogP 3.56020
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title: CAS No. 120205-48-3 | Chemsrc address: https://www.chemsrc.com/en/baike/845626.html

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