1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(4-methyl)benzoyl-D-ribofuranose

Names

[ CAS No. ]:
120143-22-8

[ Name ]:
1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(4-methyl)benzoyl-D-ribofuranose

[Synonym ]:
3-azido-1,2-bis-O-acetyl-5-O-toluoyl-3-deoxy-D-ribofuranose
3-Azido-1H-[1,2,4]triazol
1H-1,2,4-Triazole,3-azido
3-Azido-1,2,4-triazol
3-azido-1H-[1,2,4]triazole
3-Azido-1,2,4-triazole
3-azido-1,2-di-O-acetyl-5-O-(p-toluoyl)-3-deoxy-D-ribofuranose

Biological Activity

[Description]:

1,2-Di-O-acetyl-3-azido-3-deoxy-5-O-(4-methyl)benzoyl-D-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₉N₃O₇

[ Molecular Weight ]:
377.35

[ Exact Mass ]:
377.12200

[ PSA ]:
137.88000

[ LogP ]:
1.50316

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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