Quinupristin

Names

[ CAS No. ]:
120138-50-3

[ Name ]:
Quinupristin

Biological Activity

[Description]:

Quinupristin is a streptogramin antibiotic. Quinupristin blocks peptide bond synthesis to prevent the extension of polypeptide chains and promote the detachment of incomplete protein chains in the bacterial ribosomal subunits[1] [2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Quinupristin/dalfopristin is a combination of streptogramin antibiotics used to against infections.Quinupristin/dalfopristin targets the 23S rRNA of most Gram-positive bacteria as well as those of certain Gram-negative bacteria[1]. Quinupristin/dalfopristin is reportedly effective against Mycoplasma spp[1].

[References]

[1]. Gurk-Turner C. Quinupristin/dalfopristin: the first available macrolide-lincosamide-streptogramin antibiotic. Proc (Bayl Univ Med Cent). 2000 Jan;13(1):83-6.

[2]. Tantibhedhyangkul W, et al. Anti-Mycoplasma Activity of Daptomycin and Its Use for Mycoplasma Elimination in Cell Cultures of Rickettsiae. Antibiotics (Basel). 2019 Aug 21;8(3).

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Molecular Formula ]:
C₅₃H₆₇N₉O₁₀S

[ Molecular Weight ]:
1022.22000

[ Exact Mass ]:
1021.47000

[ PSA ]:
256.50000

[ LogP ]:
3.12360

[ Index of Refraction ]:
1.662

Related Compounds

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