ODN D-SL03

ODN D-SL03 is a C class CpG oligonucleotides, can induce stimulate PBMCs to produce high level of IFN-α. ODN D-SL03 can activate human B cells, NK cells and mononuclear cells and up-regulate expression of CD80, CD86 and HLA-DR on the surface of subsets in human PBMCs. ODN D-SL03 also can inhibit the growth of the tumor. ODN D-SL03 sequence: 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'[1].

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> IFNAR

Research Areas >> Inflammation/Immunology

IFN-α[1]

ODN D-SL03 (0-3 μg/mL; 36 h) significantly induces IFN-α production in PBMCs at 0.19 μg/mL[1]. ODN D-SL03 (3 μg/mL; 18 or 36 h) activates immune cells including B, NK, T and monocyte cells[1].

ODN D-SL03 (25 μg per mouse; Peritumoral injection) induces significant inhibition of tumor growth[1]. Animal Model: Female BALB/c mice (6-8 weeks; inoculated with 5×105 EMT6 cells)[1] Dosage: 25 μg per mouse Administration: Peritumoral injection, six times in one-day interval, for 0-100 days Result: Induced significant inhibition of tumor growth.

[1]. Yang L, et al. CpG oligodeoxynucleotides with double stem-loops show strong immunostimulatory activity. Int Immunopharmacol. 2013 Jan;15(1):89-96.