Coptisine sulfate

Names

[ CAS No. ]:
1198398-71-8

[ Name ]:
Coptisine sulfate

[Synonym ]:
6,7-Dihydro[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquinolino[3,2-a]isoquinolin-5-ium hydrogen sulfate
Coptisine sulfate

Biological Activity

[Description]:

Coptisine Sulfate is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)

Research Areas >> Metabolic Disease

[Target]

IC50: 6.3 μM (IDO)[1] Ki: 5.8 μM (IDO)[1]

[References]

[1]. Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₅NO₈S

[ Molecular Weight ]:
417.389

[ Exact Mass ]:
417.051849

Related Compounds

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