1198398-71-8

1198398-71-8 structure

Name: Coptisine sulfate
Chemical Name: Coptisine sulfate
CAS Number: 1198398-71-8
Molecular Formula: C₁₉H₁₅NO₈S
Molecular Weight: 417.389
Catalog: Signaling Pathways Metabolic Enzyme/Protease Indoleamine 2,3-Dioxygenase (IDO)
Create Date: 2018-06-27 08:49:43
Modify Date: 2025-08-26 10:41:31
Coptisine Sulfate is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM[1].

Name	Coptisine sulfate
Synonyms	6,7-Dihydro[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquinolino[3,2-a]isoquinolin-5-ium hydrogen sulfate Coptisine sulfate

Description	Coptisine Sulfate is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO) Research Areas >> Metabolic Disease
Target	IC50: 6.3 μM (IDO)[1] Ki: 5.8 μM (IDO)[1]
References	[1]. Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302.