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SB 206553 2HCl

Names

[ CAS No. ]:
1197334-04-5

[ Name ]:
SB 206553 2HCl

[Synonym ]:
5-Methyl-N-(pyridin-3-yl)-3,5-dihydropyrrolo[2,3-f]indole-1(2H)-carboxamide hydrochloride (1:1)
Pyrrolo[2,3-f]indole-1(2H)-carboxamide, 3,5-dihydro-5-methyl-N-3-pyridinyl-, hydrochloride (1:1)
5-Methyl-N-(3-pyridinyl)-3,5-dihydropyrrolo[2,3-f]indole-1(2H)-carboxamide hydrochloride (1:1)
MFCD01530064

Biological Activity

[Description]:

SB 206553 is a potent and selective 5-HT2B/5-HT2C receptor antagonist with pA2 of 8.89 for rat 5-HT2B, pKi of 7.92 for human 5-HT2C, displays >80-fold selectivity over other 5-HT receptor subtypes; exhibits anxiolytic-like properties both in vitro and in vivo. Anxiety Discontinued

[References]

References 1. Forbes IT, et al. J Med Chem. 1995 Jul 7;38(14):2524-30. 2. Upton N, et al. Eur J Pharmacol. 1998 Oct 16;359(1):33-40. 3. Kennett GA, et al. Br J Pharmacol. 1996 Feb;117(3):427-434. 4. Porras G, et al. Neuropsychopharmacology. 2002 Mar;26(3):311-24. View Related Products by Target 5-HT Receptor Anxiety

Chemical & Physical Properties

[ Molecular Formula ]:
C17H17ClN4O

[ Molecular Weight ]:
328.796

[ Exact Mass ]:
328.109100

Related Compounds