1197334-04-5
1197334-04-5 structure
- Name: SB 206553 2HCl
- Chemical Name: 5-Methyl-N-(3-pyridinyl)-3,5-dihydropyrrolo[2,3-f]indole-1(2H)-carboxamide hydrochloride (1:1)
- CAS Number: 1197334-04-5
- Molecular Formula: C17H17ClN4O
- Molecular Weight: 328.796
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2020-01-11 14:01:28
- Modify Date: 2024-02-05 16:15:30
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SB 206553 is a potent and selective 5-HT2B/5-HT2C receptor antagonist with pA2 of 8.89 for rat 5-HT2B, pKi of 7.92 for human 5-HT2C, displays >80-fold selectivity over other 5-HT receptor subtypes; exhibits anxiolytic-like properties both in vitro and in vivo. Anxiety Discontinued
| Name | 5-Methyl-N-(3-pyridinyl)-3,5-dihydropyrrolo[2,3-f]indole-1(2H)-carboxamide hydrochloride (1:1) |
|---|---|
| Synonyms |
5-Methyl-N-(pyridin-3-yl)-3,5-dihydropyrrolo[2,3-f]indole-1(2H)-carboxamide hydrochloride (1:1)
Pyrrolo[2,3-f]indole-1(2H)-carboxamide, 3,5-dihydro-5-methyl-N-3-pyridinyl-, hydrochloride (1:1) 5-Methyl-N-(3-pyridinyl)-3,5-dihydropyrrolo[2,3-f]indole-1(2H)-carboxamide hydrochloride (1:1) MFCD01530064 |
| Description | SB 206553 is a potent and selective 5-HT2B/5-HT2C receptor antagonist with pA2 of 8.89 for rat 5-HT2B, pKi of 7.92 for human 5-HT2C, displays >80-fold selectivity over other 5-HT receptor subtypes; exhibits anxiolytic-like properties both in vitro and in vivo. Anxiety Discontinued |
|---|---|
| References | References 1. Forbes IT, et al. J Med Chem. 1995 Jul 7;38(14):2524-30. 2. Upton N, et al. Eur J Pharmacol. 1998 Oct 16;359(1):33-40. 3. Kennett GA, et al. Br J Pharmacol. 1996 Feb;117(3):427-434. 4. Porras G, et al. Neuropsychopharmacology. 2002 Mar;26(3):311-24. View Related Products by Target 5-HT Receptor Anxiety |
| Molecular Formula | C17H17ClN4O |
|---|---|
| Molecular Weight | 328.796 |
| Exact Mass | 328.109100 |