ST-1006

Names

[ CAS No. ]:
1196994-11-2

[ Name ]:
ST-1006

Biological Activity

[Description]:

ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

H4 receptor:7.94 (pKi)


[In Vitro]

ST-1006 (10 μM) 是一种有效的嗜碱性粒细胞迁移诱导剂，可诱导嗜碱性粒细胞迁移[2]。 ST-1006 (0-100 μM) 抑制 FceRI 介导的嗜碱性粒细胞激活并降低 FceRI 激活的嗜碱性粒细胞的 CD63 和 CD203c 表达水平[2]。

[In Vivo]

ST-1006 (1-100 mg/kg；s.c.；雄性 CD-1 小鼠) 具有抗炎作用和止痒作用[1]。 Animal Model: Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)[1] Dosage: 1-100 mg/kg Administration: Subcutaneous injection Result: Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.

[References]

[1]. Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397.  

[2]. Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73.  

Chemical & Physical Properties

[ Molecular Formula ]:
C16H20Cl2N6

[ Molecular Weight ]:
367.28

Related Compounds