1196994-11-2
1196994-11-2 structure
- Name: ST-1006
- Chemical Name: ST-1006
- CAS Number: 1196994-11-2
- Molecular Formula: C16H20Cl2N6
- Molecular Weight: 367.28
- Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
- Create Date: 2023-04-14 14:52:01
- Modify Date: 2024-01-02 13:08:49
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ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2].
| Name | ST-1006 |
|---|
| Description | ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect[1][2]. |
|---|---|
| Related Catalog | |
| Target |
H4 receptor:7.94 (pKi) |
| In Vitro | ST-1006 (10 μM) 是一种有效的嗜碱性粒细胞迁移诱导剂，可诱导嗜碱性粒细胞迁移[2]。 ST-1006 (0-100 μM) 抑制 FceRI 介导的嗜碱性粒细胞激活并降低 FceRI 激活的嗜碱性粒细胞的 CD63 和 CD203c 表达水平[2]。 |
| In Vivo | ST-1006 (1-100 mg/kg；s.c.；雄性 CD-1 小鼠) 具有抗炎作用和止痒作用[1]。 Animal Model: Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)[1] Dosage: 1-100 mg/kg Administration: Subcutaneous injection Result: Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg. |
| References |
| Molecular Formula | C16H20Cl2N6 |
|---|---|
| Molecular Weight | 367.28 |