NCX 470

NCX 470 is a second-generation nitric oxide (NO)-donating prostaglandin analogue. NCX 470 effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. NCX 470 can be used for the research of cular hypertension and glaucoma[1][2].

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

NCX 470 shows a better intraocular pressure-lowering efficacy than that of equimolar doses of bimatoprost in well-established animal models of glaucoma and ocular hypertension[1]. NCX 470 (0.14% 30 μL; instillation; once) reduces IOP in transient ocular hypertensive rabbits[2]. NCX 470 (0.042% 30 μL; instillation; once) is more effective than equimolar bimatoprost in ONT-dogs and in OHT-monkeys at 18 hours post dosing[2]. Animal Model: New Zealand white rabbits with 0.1 mL 5% sodium chloride solution injection[2] Dosage: 0.14% Administration: Instillation; 0.14% 30 μL; once Result: Significantly blunted the IOP rise throughout the experimental period in transiently ocular hypertensive New Zealand white rabbits.