FLUTRIMAZOLE
Names
[ CAS No. ]:
119006-77-8
[ Name ]:
FLUTRIMAZOLE
[Synonym ]:
Flutrimazolum
1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-Imidazol
Flutrimazole (INN)
FLUTRIMAZOLE
1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole
Micetal
Flutrimazolum [INN-Latin]
Flutrimazol [INN-Spanish]
1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole
MFCD00865591
Flutrimazol
1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
1-[o-Fluoro-a-(p-fluorophenyl)-a-phenylbenzyl]imidazole
1H-Imidazole, 1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-
UR-4056
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
457.1±40.0 °C at 760 mmHg
[ Melting Point ]:
161-166ºC
[ Molecular Formula ]:
C22H16F2N2
[ Molecular Weight ]:
346.373
[ Flash Point ]:
230.3±27.3 °C
[ Exact Mass ]:
346.128143
[ PSA ]:
17.82000
[ LogP ]:
4.95
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.590
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NI6259450
- CHEMICAL NAME :
- 1H-Imidazole, 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-
- CAS REGISTRY NUMBER :
- 119006-77-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C22-H16-F2-N2
- MOLECULAR WEIGHT :
- 346.40
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 808 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1079 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Mycoses 43(9-10) , 355-65, (2000)
A double-blind randomized comparative phase II study of flutrimazole site-release vaginal cream (1, 2 and 4%) with placebo site-release vaginal cream was undertaken in patients with acute vulvovaginal...
Efficacy of flutrimazole 1% powder in the treatment of tinea pedis.Mycoses 46(3-4) , 126-31, (2003)
The aim of the study was to compare the efficacy and tolerability of flutrimazole 1% powder vs. bifonazole 1% powder in treating tinea pedis. A multicentre, double blind, randomized, parallel and comp...
Study to compare the efficacy and safety of fluconazole cream with flutrimazole cream in the treatment of superficial mycosis: a multicentre, randomised, double-blind, phase III trial.Mycoses 53(6) , 522-9, (2010)
Fluconazole, which is a drug of the azole family, is safely used in systemic treatment of oral and intravenous injection, but it is difficult to use fluconazole as a topical application because of its...