Thiabendazole-d4

Names

[ CAS No. ]:
1190007-20-5

[ Name ]:
Thiabendazole-d4

[Synonym ]:
2-(1,3-Thiazol-4-yl)(4,5,6,7-2H4)-1H-benzimidazole
1H-Benzimidazole-4,5,6,7-d4, 2-(4-thiazolyl)-

Biological Activity

[Description]:

Thiabendazole-d4 is the deuterium labeled EIDD-1931. EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent anti-virus agent. EIDD-1931 effectively inhibits the replication activity of venezuelan equine encephaliti

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[75].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
446.0±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₃D₄N₃S

[ Molecular Weight ]:
205.272

[ Flash Point ]:
226.2±16.9 °C

[ Exact Mass ]:
205.061172

[ LogP ]:
2.47

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.740

[ Storage condition ]:
-20°C