Hydrochlorothiazid-13C,d2

Names

[ CAS No. ]:
1190006-03-1

[ Name ]:
Hydrochlorothiazid-13C,d2

[Synonym ]:
Bremil-13C,d2
Aquarius-13C,d2
Hydrex-13C,d2
Hydrochlorothiazide-13C,d2
Diurizid-13C,d2
Drenol-13C,d2
Dichlotride-13C,d2
Thiuretic-13C,d2
Cidrex-13C,d2
Pantemon-13C,d2

Biological Activity

[Description]:

Hydrochlorothiazid-13C,d2 is the 13C- and deuterium labeled. Hydrochlorothiazide (HCTZ), an orally active diuretic drug of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad
Research Areas >> Cardiovascular Disease
Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad
Research Areas >> Metabolic Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[71].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

[2]. Duarte, J.D. and R.M. Cooper-DeHoff, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther, 2010. 8(6): p. 793-802.

[3]. Jinghong Luo, et al. Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats. Cardiovasc Ther. 2017 Apr;35(2).

[4]. Magdy M Abdelquader, et al. Inhibition of Co-Crystallization of Olmesartan Medoxomil and Hydrochlorothiazide for Enhanced Dissolution Rate in Their Fixed Dose Combination. AAPS PharmSciTech. 2018 Dec 17;20(1):3.

Chemical & Physical Properties

[ Molecular Formula ]:
C613CH6D2ClN3O4S2

[ Molecular Weight ]:
300.74

[ Exact Mass ]:
299.98000

[ PSA ]:
135.12000

[ LogP ]:
2.97740

Related Compounds