Pristanic acid

Names

[ Name ]:
Pristanic acid

[Synonym ]:
(2S,6R,10R)-2,6,10,14-tetramethylpentadecanoic acid
Pristaninsaeure
acide pristanique
Pristanic acid solution
2,6,10,14-Tetramethyl-pentadecansaeure
2,6,10,14-tetramethylpentadecanoic
acido pristanico
2,6,10,14-Tetramethylpentadecanoic acid
2,6,10,14-tetramethyl-pentadecanoic acid
MFCD05664739

Biological Activity

[Description]:

Pristanic acid is an endogenous metabolite present in Blood that can be used for the research of Alpha Methylacyl CoA Racemase Deficiency and Zellweger Syndrome[1][2][3].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite

[In Vitro]

Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].

[References]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. McLean BN, et al. A new defect of peroxisomal function involving pristanic acid: a case report. J Neurol Neurosurg Psychiatry. 2002 Mar;72(3):396-9.

[3]. Baumgartner MR, et al. Clinical approach to inherited peroxisomal disorders: a series of 27 patients. Ann Neurol. 1998 Nov;44(5):720-30.

Chemical & Physical Properties

[ Density]:
0.882g/cm3

[ Boiling Point ]:
408ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₃₈O₂

[ Molecular Weight ]:
298.50400

[ Flash Point ]:
14ºC

[ Exact Mass ]:
298.28700

[ PSA ]:
37.30000

[ LogP ]:
6.14620

[ Appearance of Characters ]:
ethanol solution

[ Vapour Pressure ]:
8.48E-08mmHg at 25°C

[ Index of Refraction ]:
1.453

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F: Flammable;

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
S7

[ RIDADR ]:
UN 1170 3/PG 2

[ WGK Germany ]:
1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

New insights into the peroxisomal protein inventory: Acyl-CoA oxidases and -dehydrogenases are an ancient feature of peroxisomes.

Biochim. Biophys. Acta 1853(1) , 111-25, (2014)

Peroxisomes are ubiquitous organelles which participate in a variety of essential biochemical pathways. An intimate interrelationship between peroxisomes and mitochondria is emerging in mammals, where...

Peroxisomal bifunctional enzyme deficiency.

J. Clin. Invest. 83(3) , 771-7, (1989)

Peroxisomal function was evaluated in a male infant with clinical features of neonatal adrenoleukodystrophy. Very long chain fatty acid levels were elevated in both plasma and fibroblasts, and beta-ox...

Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro.

Cancer Epidemiol. Biomarkers Prev. 12(8) , 775-83, (2003)

An enzyme previously identified as alpha-methylacyl-CoA racemase (AMACR) is overexpressed in high-grade prostatic intraepithelial neoplasia and in a majority (60-100%) of prostate cancers (CaPs) as co...

Related Compounds

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