Lck Inhibitor III

Names

[ CAS No. ]:
1188890-30-3

[ Name ]:
Lck Inhibitor III

[Synonym ]:
2-(1H-Benzo[d]imidazol-1-yl)-N-(5-methoxy-2-methylphenyl)-6-(2-morpholinoethoxy)pyrimidin-4-amine, hydrate

Biological Activity

[Description]:

Lck Inhibitor III (compound 12h) is a potent Lck inhibitor, with an IC50 of 867 nM. Lck Inhibitor III inhibits IL-2 synthesis in Jurkat cells, with an IC50 of 1.270 μM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src

[Target]

IL-2

Lck:867 nM (IC50)


[References]

[1]. Sabat M, et al. The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck). Bioorg Med Chem Lett. 2006 Dec 1;16(23):5973-7.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H28N6O3・H2O

[ Molecular Weight ]:
478.55

[ Water Solubility ]:
Soluble in DMSO (100 mg/ml), and ethanol (25 mg/ml).

Related Compounds