BMS-764459

Names

[ Name ]:
BMS-764459

Biological Activity

[Description]:

BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Signaling Pathways >> GPCR/G Protein >> CRFR

Research Areas >> Neurological Disease

[Target]

CRF1[1], CYP1A1[2]

[References]

[1]. David K. Leahy, et al. Development of an Efficient Synthesis of Two CRF Antagonists for the Treatment of Neurological Disorders. Org. Process Res. Dev. 2010, 14, 5, 1221-1228.

[2]. Simic D, et al. MicroRNA changes associated with atypical CYP1A1 inducer BMS-764459. Toxicology. 2013 Sep 15;311(3):169-77.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₁F₂N₅O₃

[ Molecular Weight ]:
405.39900

[ Exact Mass ]:
405.16100

[ PSA ]:
105.29000

[ LogP ]:
2.49118

Related Compounds

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