Tizanidine-d4

Names

[ CAS No. ]:
1188331-19-2

[ Name ]:
Tizanidine-d4

[Synonym ]:
Tizanidine-d4

Biological Activity

[Description]:

Tizanidine-d4 is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Kamen L, et al. A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. Curr Med Res Opin. 2008 Feb;24(2):425-39.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H4ClD4N5S

[ Molecular Weight ]:
257.73600

[ Exact Mass ]:
257.04400

[ PSA ]:
90.44000

[ LogP ]:
1.55320

Related Compounds