ularitide

Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure[1][2][4][5].

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Ularitide increases the amount of cyclic nucleotides and decreases the raise in permeability in HUVEC cells[2]. Ularitide (1 nM-1 μM, 15 min) reverses methacholine-evoked contraction in bovine bronchi[3]. Ularitide (1 μM, 0-300 s) increases cyclic GMP levels in the presence of phosphoramidon in bovine bronchi[3].

Ularitide (10 nmol/kg, s.c., once) increases in urine volume and sodium excretion in arteriovenous (AV) fistula dogs[1]. Animal Model: Female dogs with or without surgically induced chronic aortocaval fistula[1] Dosage: 5 and 10 pmol/kg/min Administration: i.v. infusions for for 75 min, and thereafter at 10 pmol/kg/min for another 75 min. Result: Increased in urine volume and sodium excretion with high-output CHF.