MTIC-d3

Names

[ Name ]:
MTIC-d3

[Synonym ]:
4-[(1E)-3-(2H3)Methyl-1-triazen-1-yl]-1H-imidazole-5-carboxamide
1H-Imidazole-4-carboxamide, 5-[(1E)-3-(methyl-d3)-1-triazen-1-yl]-

Biological Activity

[Description]:

MTIC-d3 is deuterium labeled MTIC. MTIC is the active metabolite of Temozolomide (TMZ). MITC has lower bioavailability in the brain compared with TMZ, because the drug’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Ramalho MJ, et al. Biophysical interaction of temozolomide and its active metabolite with biomembrane models: The relevance of drug-membrane interaction for Glioblastoma Multiforme therapy. Eur J Pharm Biopharm. 2019;136:156-163.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
486.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅H₅D₃N₆O

[ Molecular Weight ]:
171.18

[ Flash Point ]:
247.9±31.5 °C

[ Exact Mass ]:
171.094788

[ LogP ]:
0.17

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.741

Related Compounds

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