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Mephenytoin-d3

Names

[ CAS No. ]:
1185101-86-3

[ Name ]:
Mephenytoin-d3

[Synonym ]:
5-ethyl-5-phenyl-3-(trideuteriomethyl)imidazolidine-2,4-dione

Biological Activity

[Description]:

(Rac)-Mephenytoin-d3 is a labelled racemic Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Klaassen T, et al. Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity. Eur J Clin Pharmacol. 2008;64(4):387-398.

[3]. Relling MV, et al. Mephenytoin phenotyping: lack of haematologic effect and timing of urine collections. Pharmacogenetics. 1991;1(1):42-49.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H11D3N2O2

[ Molecular Weight ]:
221.27000

[ Exact Mass ]:
221.12400

[ PSA ]:
52.90000

[ LogP ]:
1.05140

Related Compounds