BX-2819

Names

[ Name ]:
BX-2819

Biological Activity

[Description]:

BX-2819 is a Hsp90 inhibitor with an IC50 value of 41 nM. BX-2819 inhibits the proliferation of cancer cells. BX-2819 can significantly inhibit the growth of NCI-N87 and HT-29 tumors in nude mice[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[Target]

HSP90:41 nM (IC50)

HSP70

[References]

[1]. Feldman RI, et al. Potent triazolothione inhibitor of heat-shock protein-90. Chem Biol Drug Des. 2009 Jul;74(1):43-50.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₄N₄O₄S

[ Molecular Weight ]:
428.50

Related Compounds

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