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AG-126

Names

[ CAS No. ]:
118409-62-4

[ Name ]:
AG-126

[Synonym ]:
(3-hydroxy-4-nitrobenzylidene)propanedinitrile
Propanedinitrile, 2-[(3-hydroxy-4-nitrophenyl)methylene]-
Tyrphostin AG 126
Tyrphostin AG127
AG-126
(3-Hydroxy-4-nitrobenzylidene)malononitrile
AG 127
AG126

Biological Activity

[Description]:

AG126 is a tyrosine kinase inhibitor which can prevent the activation of mitogen-activated protein kinase p42MAPK (ERK2).

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

ERK2


[References]

[1]. Cuzzocrea S, et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Am J Pathol. 2000 Jul;157(1):145-58.


[Related Small Molecules]

SCH772984 | Ravoxertinib | Honokiol | Sodium tauroursodeoxycholate | LY3214996 | Ulixertinib (BVD-523) | TIC10 | Astragaloside IV | XMD8-92 | LM22B 10 | VX-11e | FR 180204 | Mogrol | Pluripotin | AX 15836

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
381.9±42.0 °C at 760 mmHg

[ Melting Point ]:
184 °C

[ Molecular Formula ]:
C10H5N3O3

[ Molecular Weight ]:
215.165

[ Flash Point ]:
184.8±27.9 °C

[ Exact Mass ]:
215.033096

[ PSA ]:
113.63000

[ LogP ]:
1.66

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.689

[ Storage condition ]:
−20°C

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
23/24/25

[ Safety Phrases ]:
26-36-45

[ WGK Germany ]:
3

Related Compounds