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Sodium Taurodeoxycholate

Names

[ CAS No. ]:
1180-95-6

[ Name ]:
Sodium Taurodeoxycholate

[Synonym ]:
MFCD00003671
Ethanesulfonic acid, 2-[[(3α,5β,12α,20R)-3,12-dihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1)
Sodium 2-(((3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl)amino)ethane-1-sulphonate
EINECS 214-652-0
Sodium 2-{[(3α,5β,12α,20R)-3,12-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate
Taurodeoxycholate sodium salt
Sodium Taurodeoxycholate
Taurodeoxycholic acid sodiuM salt
Sodium taurodeoxycholate hydrate

Biological Activity

[Description]:

Taurodeoxycholate sodium salt is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) inhibits various inflammatory responses[1] [2][3].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Villavicencio-Queijeiro A, et al. The fully-active and structurally-stable form of the mitochondrial ATP synthase of Polytomella sp. is dimeric. J Bioenerg Biomembr. 2009 Feb;41(1):1-13.

[2]. Kispal G,et al. Isolation and characterization of 3-hydroxyacyl coenzyme A dehydrogenase-binding protein from pig heart inner mitochondrial membrane. J Biol Chem. 1986 Oct 25;261(30):14209-13.

[3]. Choi HJ, et al. Evaluation of acute and subacute toxicity of sodium taurodeoxycholate in rats. Drug Chem Toxicol. 2019 Jun 19:1-9.

Chemical & Physical Properties

[ Melting Point ]:
168 °C (dec.)(lit.)

[ Molecular Formula ]:
C26H44NNaO6S

[ Molecular Weight ]:
521.685

[ Exact Mass ]:
521.278687

[ PSA ]:
135.14000

[ LogP ]:
4.52640

[ Storage condition ]:
-20℃

[ Water Solubility ]:
soluble

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R37

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds