bromazine

Names

[ CAS No. ]:
118-23-0

[ Name ]:
bromazine

[Synonym ]:
Histabromamine
N-2-(4-bromobenzhydryloxy)ethyldimethylamine
EINECS 204-238-8
bromodiphenhydramine
Bromanautine
Bromo-Benadryl
Ethanamine,2-(4-bromophenyl)phenylmethoxy-N,N-dimethyl

Biological Activity

[Description]:

Bromodiphenhydramine (Ambodryl) is a potent antihistamine with antimicrobial property. Bromodiphenhydramine inhibits a large number of Gram negative and Gram positive bacteria. Bromodiphenhydramine can be used for cutaneous allergies research[1][2][3].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Signaling Pathways >> Anti-infection >> Bacterial

[In Vivo]

Bromodiphenhydramine (1.5 and 3 μg/g, single) protects mice against a challenge with a virulent strain of Salmonella typhimurium, and also significantly reduces the multiplication of this organism in the liver, spleen and blood of the protected animals in comparison with the unprotected controls[2].

[References]

[1]. MOLINA EB. [A new antihistaminic, bromodiphenhydramine hydrochloride, in the control of cutaneous allergies]. Sem Med. 1960 Jul 11;117:151-2. Spanish.

[2]. Dastidar SG, et al. Antibacterial activity of ambodryl and benadryl. J Appl Bacteriol. 1976 Oct;41(2):209-14.

[3]. Ray S, et al. Studies on synergism between penicillins and ambodryl (bromodiphenhydramine HCl), an antihistamine with antimicrobial property. Indian J Exp Biol. 1990 Mar;28(3):253-8. 

Chemical & Physical Properties

[ Density]:
1.259g/cm3

[ Boiling Point ]:
397.3ºC at 760mmHg

[ Molecular Formula ]:
C17H20BrNO

[ Molecular Weight ]:
334.25100

[ Flash Point ]:
194.1ºC

[ Exact Mass ]:
333.07300

[ PSA ]:
12.47000

[ LogP ]:
4.11670

Safety Information

[ HS Code ]:
2922199090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds