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Xenin-8 TFA

Names

[ CAS No. ]:
117442-28-1

[ Name ]:
Xenin-8 TFA

[Synonym ]:
xenopsin-related peptide i
xp-1
his-pro-lys-arg-pro-trp-ile-leu
xenopsin-related peptide 1
h-his-pro-lys-arg-pro-trp-ile-leu-oh

Biological Activity

[Description]:

Xenin-8, a C-terminal octapeptide, is a biologically active fragment of Xenin. Xenin is a 25-amino acid peptide of the neurotensin/xenopsin family. Xenin-8 stimulates basal insulin secretion and potentiates the insulin response to glucose in a dose-dependent manner (EC50=0.16 nM)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vitro]

Xenin-8 augments Arginine-induced insulin release (by 40%) and potentiates the glucagon responses to both Arginine (by 60%), Carbachol (by 50%). Xenin-8 counteracts the inhibition of glucagon release induced by increasing the glucose concentration[1].

[References]

[1]. Ramona A Silvestre, et al. Stimulatory effect of xenin-8 on insulin and glucagon secretion in the perfused rat pancreas. Regul Pept. 2003 Aug 15;115(1):25-9.

Chemical & Physical Properties

[ Density]:
1.43±0.1 g/cm3(Predicted)

[ Molecular Formula ]:
C51H79N15O9

[ Molecular Weight ]:
1046.27000

[ Exact Mass ]:
1045.62000

[ PSA ]:
381.83000

[ LogP ]:
4.40040

Related Compounds