BMS-665053

Names

[ Name ]:
BMS-665053

[Synonym ]:
1-Boc-D-Pyroglutamic acid ethyl ester
Ethyl Boc-D-pyroglutamate
Ethyl N-Boc-D-pyroglutamate

Biological Activity

[Description]:

BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM)[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CRFR

Research Areas >> Neurological Disease

[References]

[1]. Jianqing Li, et al. An Efficient, Direct Bis-ortho-chlorination of 4-(Difluoromethoxy)aniline and Its Application to the Synthesis of BMS-665053, a Potent and Selective Pyrazinone-Containing Corticotropin-Releasing Factor-1 Receptor Antagonist. Organic Process Research & Development, 16, 156-159.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₄Cl₃F₂N₃O₂

[ Molecular Weight ]:
424.65700

[ Exact Mass ]:
423.01200

[ PSA ]:
59.38000

[ LogP ]:
4.94140

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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