RETRA hydrochloride

Names

[ Name ]:
RETRA hydrochloride

[Synonym ]:
Reactivation of Transcriptional Reporter Activity
RETRA
2-(4,5-Dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone hydrochloride
Ethanone, 2-[(4,5-dihydro-2-thiazolyl)thio]-1-(3,4-dihydroxyphenyl)-, hydrochloride (1:1)
MFCD11114394
2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-1-(3,4-dihydroxyphenyl)ethanone hydrochloride (1:1)

Biological Activity

[Description]:

RETRA hydrochloride is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft; increases in the expression level of p73, releases p73 and poduces tumor-suppressor effects similar to the functional reactivation of p53; a p73 activator.

[References]

References 1. Kravchenko JE, et al. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7. 2. Sonnemann J, et al. Eur J Cancer. 2015 May;51(7):841-51. 3. Santag S, et al. Oncogene. 2013 Aug 8;32(32):3676-85. View Related Products by Target MDM2-p53

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁N₁₁NO₃S_2.HCl

[ Molecular Weight ]:
305.801

[ Exact Mass ]:
304.994720

Related Compounds

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