Isoglycycoumarin

Names

[ Name ]:
Isoglycycoumarin

[Synonym ]:
isoglycycoumarin
pyranocoumarin
3-(2,4-Dihydroxy-phenyl)-5-methoxy-8,8-dimethyl-7,8-dihydro-6H-pyrano[3,2-g]chromen-2-one

Biological Activity

[Description]:

Isoglycycoumarin is a flavonoid isolated from the roots of Glycyrrhiza uralensis. Isoglycycoumarin is a highly selective probe for human cytochrome P450 2A6 (CYP2A6)[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

Research Areas >> Others

[Target]

P450 2A6[2]

[References]

[1]. Li S, et al. Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5398-401.

[2]. Wang Q, et al. The prenylated phenolic natural product isoglycycoumarin is a highly selective probe for human cytochrome P450 2A6. Eur J Pharm Sci. 2017 Nov 15;109:472-479.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₀O₆

[ Molecular Weight ]:
368.38000

[ Exact Mass ]:
368.12600

[ PSA ]:
89.13000

[ LogP ]:
3.98340