Propargyl-PEG5-CH2CO2-NHS

Names

[ CAS No. ]:
1161883-51-7

[ Name ]:
Propargyl-PEG5-CH2CO2-NHS

Biological Activity

[Description]:

Propargyl-PEG4-O-C1-NHS ester (compound 8) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Kussrow A, et al. Measurement of monovalent and polyvalent carbohydrate-lectin binding by back-scatteringinterferometry. Anal Chem. 2009 Jun 15;81(12):4889-97.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₅NO₉

[ Molecular Weight ]:
387.38

[ Storage condition ]:
2-8°C

Propargyl-PEG5-CH2CO2-NHS

Names

Biological Activity

Chemical & Physical Properties

Related Compounds