7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene

Names

[ Name ]:
7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene

[Synonym ]:
[6-hydroxy-2-(4-hydroxyphenyl)-7-[4-(2-piperidin-1-ylethoxy)benzoyl]-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone

Biological Activity

[Description]:

7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist with an IC50 of 3.1 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is binding to the domain (LBD) of LRH-1[1].

[References]

[1]. Rey, J., et al. Discovery of a New Class of Liver Receptor Homolog-1 (LRH-1) Antagonists: Virtual Screening, Synthesis and Biological Evaluation. ChemMedChem,2012; 7(11), 1909–1914.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₂H₄₄N₂O₆S

[ Molecular Weight ]:
704.87400

[ Exact Mass ]:
704.29200

[ PSA ]:
127.78000

[ LogP ]:
8.04670

Related Compounds

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