BI-1950
Names
[ CAS No. ]:
1159724-42-1
[ Name ]:
BI-1950
Biological Activity
[Description]:
BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM; displays >1,000 fold selectivity against the most closely related b2-integrin Mac-1 and b1-integrin function; inhibits the production of IL-2 in human PBMC and whole blood with IC50 value of 3 nM and 120 nM, respectively; exhibits an attractive DMPK profile, BI-1950 is a excellent molecule for testing pharmacological hypotheses in vitro and in vivo.
[References]
References View Related Products by Target Other Targets
Chemical & Physical Properties
[ Molecular Formula ]:
C32H26Cl2FN7O3
[ Molecular Weight ]:
646.504