BI-1950

Names

[ Name ]:
BI-1950

Biological Activity

[Description]:

BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM; displays >1,000 fold selectivity against the most closely related b2-integrin Mac-1 and b1-integrin function; inhibits the production of IL-2 in human PBMC and whole blood with IC50 value of 3 nM and 120 nM, respectively; exhibits an attractive DMPK profile, BI-1950 is a excellent molecule for testing pharmacological hypotheses in vitro and in vivo.

[References]

References View Related Products by Target Other Targets

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₂₆Cl₂FN₇O₃

[ Molecular Weight ]:
646.504

Related Compounds

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