TLR4-IN-C34-C2-COOH

Names

[ Name ]:
TLR4-IN-C34-C2-COOH

[Synonym ]:
5-[(2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-galactopyranosyl)oxy]pentanoic acid
MFCD30802159
Pentanoic acid, 5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-

Biological Activity

[Description]:

TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

Research Areas >> Inflammation/Immunology

Signaling Pathways >> PROTAC >> PROTAC Linker

[References]

[1]. Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8(6):e65779. Published 2013 Jun 12.

Chemical & Physical Properties

[ Density]:
1.29±0.1 g/cm3(Predicted)

[ Boiling Point ]:
634.1±55.0 °C(Predicted)

[ Molecular Formula ]:
C₁₉H₂₉NO₁₁

[ Molecular Weight ]:
447.43

[ Flash Point ]:
337.3±31.5 °C

[ Exact Mass ]:
447.174072

[ LogP ]:
0.27

[ Vapour Pressure ]:
0.0±4.0 mmHg at 25°C

[ Index of Refraction ]:
1.505

[ Storage condition ]:
Inert atmosphere,Store in freezer, under -20°C

Safety Information

[ Hazard Codes ]:
Xi

TLR4-IN-C34-C2-COOH

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds