[4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea

Names

[ Name ]:
[4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea

[Synonym ]:
Urea,N-(4-((3'-chloro-6-methoxy(1,1'-biphenyl)-3-yl)methyl)phenyl)
UNII-4T436CO8BT
1-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea
[4-(3'-Chloro-6-methoxy-biphenyl-3-ylmethyl)-phenyl]-urea

Biological Activity

[Description]:

D159687 is a selective PDE4D inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Neurological Disease

[Target]

PDE4D[1]

[In Vitro]

D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment[1]. D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM[1]. Western Blot Analysis[1] Cell Line: HT-22 (mouse hippocampal cell line) Concentration: 1 μM Incubation Time: 0, 1, 3, 6, 12, 24 hours Result: Induced a transient increase in CREB phosphorylation which peaked at 6 hours after treatment. Western Blot Analysis[1] Cell Line: HT-22 (mouse hippocampal cell line) Concentration: 0.01 μM, 0.1 μM, 1 μM Incubation Time: 6 hours Result: CREB phosphorylation was optimal at 1 μM.

[In Vivo]

D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques[2]. Animal Model: Female Cynomolgus macaques (4–6 year old) [2] Dosage: 0.05, 0.5, 5 mg/kg Administration: Oral daily for a week Result: A potential recruitment or enhancement of synaptic function with increased task difficulty.

[References]

[1]. Zhang C, et al. Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System. Sci Rep. 2017 Jan 5;7:40115.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₉ClN₂O₂

[ Molecular Weight ]:
366.84

[ Exact Mass ]:
366.11400

[ PSA ]:
65.34000

[ LogP ]:
5.68380

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2924299090

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.